Onteis is developing a platform to produce non-cytotoxic treatments aimed at cancer normalization. Cancer normalization leads to the anatomical and functional reconstruction of cancerous tissues and their reintegration into the organism. This approach represents a new class of therapies designed to improve the therapeutic index (efficacy/toxicity) compared to conventional cytotoxic treatments. By avoiding cell destruction, Onteis' future treatments aim to enhance tolerance while restoring the normal function of affected tissues.
Onteis develops mathematical models that take into account several levels of the organism, and precisely the level of the tissue. They are based on the work of the interdisciplinary programme “Theoretical Foundations of Biology”, hosted at the École Normale Supérieure in Paris.